What is Glucorein PCOS? September 27, 2012 Did you happen to catch the intriguing, FACES OF PCOS “Contest” that was advertised over all of PCOS social media this past summer? FACES OF PCOS was sponsored by Napa Valley Nutritionals. The company was looking for women to share their PCOS story. I thought it was interesting that a relatively unknown supplement company was marketing a contest to women with PCOS. They surely had something up their sleeve! And so they did. On September 18th, Napa Valley Nutritionals announced a new product to help with the management of PCOS. I will admit, I am always skeptical of “new” products that pop up for women with PCOS. I think companies are finally realizing that there is a huge business opportunity in PCOS. Think about it, if at least 1 in 10 women have PCOS, and most of those women are struggling to control it, then there is a huge business opportunity for supplement companies. With a healthy dose of skepticism, I reached out to Napa Valley Nutritionals to find out more about their new product, Glucorein Medical Food for Dietary Management of PCOS. I discovered that Napa Valley Nutritionals is actually a newly formed division of Oculus a large commercial heathcare company. I had the opportunity to speak with Susan Derence, Sales and Marketing Director for Napa Valley Nutritionals last week. Susan actually has PCOS and has struggled with infertility and PCOS for many years. She was very excited to talk about this new product. She told me it has helped her bring on natural periods for the first time ever – she just turned 40. She also has experienced lots of new hair growth. The hair growth certainly peaked my interest since this is a symptom I still struggle with. Susan explained that Glucorein’s main ingredient is chlorogenic acid. Each daily dose of Glucorein PCOS contains a therapeutic dose of 1 gram of chlorogenic acid. If you watch Dr. Oz, you may have seen the episode in April about Weight Loss Supplements. Green Coffee BeanExtract was one of the solutions discussed. Dr. Oz has made green coffee bean extract and chlorogenic acid all the rage. You can see the episode and more information here: http://www.doctoroz.com/videos/miracle-pill-burn-fat-pt-1 http://www.doctoroz.com/videos/green-coffee-bean-project?page=3#copy Chlorogenic Acid The active ingredient in the green coffee bean extract is chlorogenic acid, so Glucorein PCOS really isn’t anything new. Chlorogenic acid has been on the market for a while – companies like Stevol provide it to supplement companies. You’ll find it in products like this supplement from Vitamin World or this supplement from Puritan’s Pride. But if you notice the amount in each product, you can see that you would need to take many pills to equal the therapeutic dosage of 1 gram in Glucorein PCOS. Chlorogenic acid has specifically been shown to inhibit enzyme, glucose-6-phosphatase, that promotes the formation of glucose (sugar) in the liver. So scientists believe it is the chlorogenic acid in coffee that may be responsible, at least in part, for the reduced risk of glycemic disorders like insulin resistance and diabetes. Other studies suggst that chlorogenic acid also slows the absorption of fat from food intake and it may also activate metabolism of extra fat. The most recent study on green coffee bean was published in January 2012 in the Diabetes, Metabolic Syndrome and Obesity journal. The researchers followed a group of 16 adults who supplemented with chlorogenic acids at different dosages (either 700 or 1050 milligrams per day) for 12 weeks. All 16 adults were considered overweight, as demonstrated by a BMI of greater than 25 (a normal BMI is between 18.5 and 25). The subjects lost an average of almost 18 pounds – this was 10% of their overall body weight and 4.4% of their overall body fat. If you drink a lot of coffee and are wondering if this would count instead for your chlorogenic acid dosage, roasted coffee isn’t a good source of chlorogenic acid. While roasting green coffee beans removes its naturally bitter taste of green coffee beans, it also removes a significant portion of chlorogenic acid. Green coffee beans remain one of the best natural sources for chlorogenic acid. Chloregenic acid has been shown in studies to control blood glucose, decrease insulin resistance, improve glucose tolerance and decrease plasma and liver lipids and lowers cholesterol all with little or no side effects. L-Cysteine Glucorein PCOS also contains .6grams of L-Cysteine. L-Cysteine is a naturally occurring amino acid. It is the natural origin compound of N-acetyl cysteine or NAC which is produced by chemical synthesis. L-cysteine has shown to help reduce BMI, hirsutism, fasting insulin, free testosterone, menstrual irregularity and cholesterol levels. NAC has also been proven, in conjunction with Clomid, to increase ovulation and pregnancy rates in women previously deemed “Clomid-resistant”. It also has been shown to improve hair and nail tissue which may be the reason why Susan’s hair is growing back. I have been using Glucorein PCOS for the past week. I do feel different. I feel more energized, my appetite is very stable and I really just feel good taking it. I take an envelope and mix it with water. It also has stevia, monk fruit (a Chinese fruit packed with antioxidants and Vitamin C) cranberry and lemon. It tastes like a slightly bitter and a little astringent and sour. It almost tastes like a less sweet version powdered ice tea mix. Glucorein products should be used under the supervision of a medical professional. It is $67.50 for a month supply. BOTTOMLINE: I have asked Napa Valley Nutritionals to put me in touch with Doctors that are using this supplement in their practice. I did not received a response before my deadline to get this article published, so I don’t have any anecdotal clinical information to share. I wish there were more PCOS specific studies backing the health claims of Glucorein PCOS, but alas there are not. I do think the chlorogenic acid studies as it relates to insulin resistance, as well as weight loss, are very promising. The research studies surrounding NAC and PCOS are also well known in the PCOS world. I can tell you I like the way Glucorein PCOS makes me feel and I will continue to use if for 3 months and then reevaluate. As I receive more info about Glucorein PCOS, I will publish it on my site. As with any supplement, it is important to talk to your doctor before taking. Please share your experience with chlorogenic acid and NAC or L-cysteine in the comment section below or on my Facebook page. Components Inhibit Amyloid Formation of Human Islet Amyloid Polypeptide in Vitro: Possible Link between Coffee Consumption and Diabetes Mellitus. J Agric Food Chem. 2011 Dec 28;59(24):13147-55. Epub 2011 Nov 21. Click Here for Article Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial. Am J Clin Nutr. 2010 Apr;91(4):950-7. Epub 2010 Feb 24. Click Here for Article Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance. Diabetes Care. 2009 Jun;32(6):1023-5. Epub 2009 Mar 26. Click Here for Article Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on incretin hormones. Nutr Metab (Lond). 2011 Feb 7;8:10. Click Here for Article Contribution of chlorogenic acids to the inhibition of human hepatic glucose-6-phosphatase activity in vitro by a standardized decaffeinated green coffee extract. J Agric Food Chem. 2010 Apr 14;58(7):4141-4. Antidiabetic medicinal plants as a source of alpha glucosidase inhibitors. Curr Diabetes Rev. 2010 Jul;6(4):247-54. Review. Click Here for Article “Coffee consumption and risk of type 2 diabetes in Finnish twins,” Int J Epidemiol, 33:3 (2004), 616-617. Click Here for Article “Coffee consumption and risk of type 2 diabetes mellitus,” Lancet, 361:9358 (2003), 703-704. Click Here for Article “Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine,” Am J Clin Nutr, 78:4 (2003), 728-733. Click Here for Article 12. “Coffee consumption and risk of type 2 diabetes mellitus,” Lancet, 360:9344 (2002), 1477-1478. Click Here for Article 10. “Coffee consumption and risk of type 2 diabetes mellitus,” Lancet, 361 (2003),702-704. 11. “Coffee consumption and risk for type 2 diabetes mellitus,” Ann Intern Med, 140:1 (2004), 1-8. Click Here for Article 12. N-acetylcysteine as an adjuvant to clompiphene citrate for successful induction of ovulation in infertile patients with Polycystic ovary syndrome. Salehpour S, Akbari Sene A, Saharkhiz N, Sohrabi MR, Moghimian F. J Obstet Gynaecol Res. 2012 Sep;38(9):1182-6. doi: 10.1111/j.1447-0756.2012.01844.x. Epub 2012 Apr 30.