Myo-inositol, Melatonin and OvaBoost for increased Fertility May 24, 2013 Last summer I wrote a post about myo-inositol and how it helps PCOS. I also introduced a myo-inositol supplement sold under the name Pregnitude. Pregnitude is a myo-inositol and folic acid nutritional supplement that has been around for years in Europe where it is known as INOFOLIC and is made in Italy by LO.LI Pharma. U.S based Everett Laboratories Inc. is now distributing this same product under the name Pregnitude in the U.S. market. LO.LI Pharma also markets another myo-inositol product called INOFOLIC PLUS. This is blend of myo-inositol, folic acid and melatonin. This product is not sold in the U.S to my knowledge. Melatonin is a hormone and a powerful antioxidant produced in your brain while you are asleep and it is completely dark (this is one of the reasons I wear a sleep eye mask at night) Since the invention of electricity, many of us sleep with night lights or even outside street lights that brighten our rooms at night. Our exposure to complete darkness is really limited and this impairs the production of melatonin. The benefit of the added melatonin is that melatonin plays an essential role in reproductive processes. Your ovarian follicular fluid has high levels of melatonin, and melatonin receptors are present in ovarian cells. Melatonin has been shown to have direct effects on ovarian function. I’ve added a whole list of published studies at the end of this post in case you are interested. If you’re not producing enough melatonin on your own, this may be adding to infertility issues. I have been able to find a supplement which is available in the US that includes 1/2 of the therapeutic dosage of myo-inositol and folic acid that you get in Pregnitude but it also contains 2 mg of melatonin. The supplement is called OvaBoost and it is sold by Fairhaven Health the makers or ovulation predicators and many other fertility supplements. It is manufactured in the USA in a GMP-certified facility. If you are concerned about the reduced amount of myo-inositol, it would be easy to supplement the additional 2mg of myo-inositol with one dose of Pregnitude or another myo-inositol like Metagenics or Pure Encaspulations. Research indicates that egg cells are highly susceptible to harm from free radicals, the unstable oxygen molecules that are produced as the body breaks down toxins. And, to function in a healthy way, egg cells need to produce a tremendous amount of energy. OvaBoost was to include key antioxidants to protect egg cells from the damaging effects of free radicals and to help egg cells produce the energy they need for successful conception and implantation. OvaBoost contains four additional antioxidant ingredients, Vitamin E, grapeseed extract, Coenzyme Q10 (CoQ10) and alpha lipoic acid, to help ensure your egg cells are adequately protected from the damaging effects of free radicals. CoQ10 also plays an important role in energy production within egg cells. Once conception occurs, the amount of cell division that occurs to allow the egg to grown into an embryo and successfully implant into the wall of the uterus requires a tremendous amount of energy. CoQ10 works within the mitochondria (the energy powerhouse of the cell) of the egg cell to help ensure that energy production is optimal. OvaBoost retails at $28.95 for a 30 day supply and the recommended dose is 4 capsules daily in divided doses. While Fairhaven Health does ship this internationally, it is also available via Amazon. I reached out to the Fairhaven Health and they were happy to offer a 15% discount on your first order of Ovaboost to Divas. Just use the coupon code: PCOSDIVA. (Full disclosure: I am not an affiliate of this product DO NOT receive compensation on the sales of Ovaboost from Fairhaven Health) Here are several citations specifically related to the importance of melatonin for egg quality/ovarian function: The melatonin level 2mg in OvaBoost is a level commensurate with the dosage used in studies that demonstrated improvement in egg quality when taken together with myo-inositol and folic acid. Effect of the treatment with myo-inositol plus folic acid plus melatonin in comparison with a treatment with myo-inositol plus folic acid on oocyte quality and pregnancy outcome in IVF cycles. A prospective, clinical trial. Rizzo P, et al. Eur Rev Med Pharmacol Sci. 2010 Jun; 14(6): 555-61. The efficacy of melatonin administration on oocyte quality. Batioglu AS, et al. Gynecol Endocrinol. 2012 Feb; 28(2); 91-3. The role of melatonin as an antioxidant in the follicle. Tamura H, et al. Journal of Ovarian Research 2012, 5:5. Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems. Eryilmaz OG et al. J Assist Reprod Genet – 01-SEP-2011; 28(9): 815-20 Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate. Tamura H, et al. J Pineal Res 2008; 44(3): 280-7 Effect of a supplementation with myo-inositol plus melatonin on oocyte quality in women who failed to conceive in previous in vitro fertilization cycles for poor oocyte quality: a prospective, longitudinal, cohort study. Unfer V, et al. Gynecol Endocrinol. 2011 Nov;27(11):857-61. Contribution of myo-inositol and melatonin to human reproduction. Carlomagno G, et al. Eur J Obstet Gynecol Reprod Biol. 2011 Dec;159(2):267-72. Melatonin as a free radical scavenger in the ovarian follicle. Tamura H, et al. Endocr J. 2012 Nov 22. Effects of melatonin in perimenopausal and menopausal women: our personal experience. Bellipanni G, et al. Ann Ny Acad Sci 2005 Dec;1057:393-402. Effects of melatonin in perimenopausal and menopausal women: a randomized and placebo controlled study. Bellipanni G, et al. Exp Gerontol 2001 Feb; 36(2):297-310 Here are several citations related to the protective benefits of antioxidants and the detrimental impact of oxidative stress on female fertility: Antioxidants to enhance fertility: role of eNOS and potential benefits. Visioli F, Hagen TM. Pharmacol Res. 2011 Nov;64(5):431-7. Coenzyme Q10 content in follicular fluid and its relationship with oocyte fertilization and embryo grading. Turi A, et al. Arch Gynecol Obstet. 2012 Apr;285(4):1173-6. The effects of oxidative stress on female reproduction: a review. Agarwal A, et al. Reprod Biol Endocrinol. 2012 June 29; 10(1): 49. Age related changes in mitochondrial function and new approaches to study redox regulation in mammalian oocytes in response to age or maturation conditions. Eichenlaub-Ritter U, et al. Mitochondrion. 2011 Sep;11(5):783-96.