ASK AMY: Does Pregnitude Really Work for PCOS? - PCOS Diva
ASK AMY: Does Pregnitude Really Work for PCOS?

Ask Amy: Does Pregnitude really work? Tara, Chicago, IL

Amy says:  For those Divas who haven’t heard of Pregnitude yet, please read my Pregnitude post and Myo-inositol post. To answer Tara’s question, I must defer to one of the nation’s top practicing docs.  I turned to Scott Roseff, MD, FACOG, a Reproductive Endocrinologist and PCOS Expert with the South Florida Institute for Reproductive Medicine (SFIRM) in Boca Raton, FL. He helps women struggling with infertility and PCOS on a daily basis.

Scott Roseff, MD, FACOG

Dr. Roseff is truly a pioneer in using myo-inositol as a therapy for PCOS patients. He was actually the first doctor to bring INOFOLIC or Pregnitude (it is called INOFOLIC in Europe) to the states from Italy to use in practice 3 years ago. Dr. Roseff told me has been thrilled with the results.

” Giving PCOS patients Pregnitude helps to replace the necessary deficient nutrient and can improve insulin resistance.  I have also seen improved ovarian function, improved ovulation frequency and it promotes menstrual cycle regularity.  My protocol is for women to try Pregnitude first, before Clomid, because my experience has been that women on Pregnitude ovulate as frequently as patients taking Clomid but without the troublesome side effects like moodiness.”

Dr. Roseff also specializes in IVF.  He finds that women who may not be able to afford multiple IVF cycles, go on to take Pregnitude and then often get pregnant on their own. He also explained that, “My IVF patients have significantly better quality eggs and embryos after taking Pregnitude.”

Dr. Roseff has also found that Pregnitude improves insulin-resistance, as well as metformin, in women with PCOS.  This is great news for women like me who just can’t tolerate metformin.  He anecdotally also revealed that many women on Pregnitude see a reduction in acne and hirtuism, as well as, experience more stable moods and less anxiety.

The dosage he prescribes is 1 dose of Pregnitude 2x a day.  He finds that 99% of his patients tolerate Pregnitude just fine and the few that may have some slight gastrointestinal issues find that if they decrease the dose to 1x a day for a week and then try to return to twice per day thereafter, the issues resolve.

When I asked Dr. Roseff if he would recommend Pregnitude as a first line therapy for PCOS, he said, “Yes, but it needs to be in conjunction with diet and lifestyle modification.  There is no magic pill for PCOS.”

(I just want to state for the record, that neither Dr. Roseff, nor I, receive monetary incentive from Everett Labs the distributors of Pregnitude in the U.S.,  for any Pregnitude sales.)

You can purchase Pregnitude on Amazon here…


  • Can you take Pregnitude if you already taking Metformin?

    • Bethany – While I would say it’s OK to take Pregnitude while taking metformin, I try to switch my patients from their metformin to the more natural Pregnitude. They both help with insulin resistance, so if someone takes them together the combined effect can possibly be “too much” and may result in unwanted effects. Do NOT take them together without first discussing it with your reproductive endocrinologist/PCOS expert. And always remember – taking metformin and/or Pregnitude is not a substitute for proper lifestyle — eat right, exercise, and watch your weight! I hope this helps – Dr. Roseff (expert in PCOS)

  • Maria

    Do you think it’s safe to take Pregnitude while breastfeeding?

  • Maria – It is unknown whether Pregnitude is safe during breastfeeding (it hasn’t been studied). Therefore, I don’t recommend it.
    I hope this helps! Dr. Roseff – PCOS Expert

  • Laura

    Is there a specific time during your cycle that you should start Pregnitude? Also, do you recommend discussing this option with your RE before trying?

    • Amy

      Yes Laura, I would talk to your doctor about any supplement you begin taking. I don’t believe that there is a specific time to start during your cycle.

  • Molly

    Can Pregnitude be taken along with birth control if you’re not looking to become pregnant?

    • Amy

      Yes Molly Pregnitude can be taken with birth control.

  • Lydia

    Has there been any research on Pregnitude aiding in the prevention of miscarriage?

  • Kara

    Can you take this along with birth control?

  • nicola robinson

    I am taking a b/c pill but want to come off it completely. Does anyone recommend just taking myo-inositol or d-chiro-inositol, have their symptoms improved? i.e. weight gain and spots? Nicola

  • Heather

    If already failed with clomid and other injectables, do you still recommend Pregnitude? Have not found a pill or injectable that is able to make me ovulate or have period.

    Haven’t done IVF, my fertility doctor refused, said he couldn’t help me, and he’s the best in our state, where do i go from here?

    • Amy

      When I was speaking to Dr. Roseff he did say that he had patients that could not afford another round of IVF and went on to get pregnant with Pregnitude

    • Carrie

      I was a poor responder to Clomid and I hyperstimmed on injects. I went back to Clomid for a pseudo “break cycle” while awaiting my next round of injects, added Inofolic + to the mixture (I’m in Europe) and became pregnant with my daughter. Even though I still responded poorly to Clomid (cycle day 38 ovulation on 150mg) I believe the Inofolic greatly improved my egg quality. I will start it again next cycle as we’re trying for number two. Good luck.

      • Amy

        Thanks for the feedback Carrie

  • Mariannag7282

    On average, how long did Dr. Roseff’s patients take Pregnitude before seeing a change in their cycles? Would you recommend taking a break from Clomid to see if Pregnitude can regulate my cycles?

    • Amy

      Dr. Roseff said it can take 3-6 months for it to take full effect. I would talk to your doctor about taking a break from clomid.

  • Jennifer

    I just want to say for the readers. I skipped the Pregnitude and went straight to the Myo-Inositol and got the required amount of Folic Acid from my prenatals and it is the same effect, just cheaper. Since I’ve started taking it at the beginning of July, I’ve gotten my period on my own this cycle and actually ovulated last cycle even though I had just started taking the Myo-Inositol, where I hadn’t ovulated since October of 2011. I take 1000mg 2 times a day and I purchased it from Puritan’s Pride. Just trying to help save people some money because buying it out separately saves tons of cash! Good luck everyone!

    • Mariannag7282

      Is it called just Inositol when you buy it through another company?

      • Amy

        There are 9 forms of inositol. Companies like Pure Encapsulations and Metagenics also have just a myo-inositol product

    • Angie

      I contacted Puritan”s Pride & they informed me that the inositol they sell is not myo-inositol

      • Amy

        Thanks Angie for letting us know!

  • amanda

    I have been on pregnitude for about 2 and a half weeks. When should i expect my period?

    • Amy

      Amanda – From my research, I understand you need to give it 3-6 months to take full effect. Of course it may be less.

  • Naomi D


    Can this product ne used safely for post menopausal women who want to address insulin resistance/diabtes who also have PCOS?



    • Amy

      I would talk to your doctor but it seems so.

  • Michelle

    I wish Pregnitude was available here! My hubby and I are stationed overseas right now on a tiny island and the limited health care is horrible! I honestly could not have been diagnosed at a worse time (diagnosed March 2011). I have an appointment on Friday with OB/GYN and I am going to ask about Pregnitude again. Maybe if I’m persistent about it they will eventually have it in stock at the Pharmacy, because I know there has to be a few other women on this island who have PCOS and feel the same way I do! It’s very frustrating!

    • Amy

      Be a Diva! You might also look at Inofolic. It is the same product but distributed through Europe under that name.

  • chrissy

    Can I take both doses of Pregnitude at the same time?

    • Amy

      Chrissy – they should be taken one in morning and one in evening.

  • Gamma

    Hi! I have 1 successful IVF (DD 12/12) and failed recent IVF with poor embryo quality. I am age 41, healthy, nml BMI and no Dx of PCOS. How strong is the evidence for Pregnitudes ability to improve egg quality for AMA? Has anyone tried the addition of melatonin for this purpose?

    • Amy

      From what I saw myo-inositol has strong evidence that it improves egg quality

  • Cara

    I take 5000 iu of vit d3 and b12 daily is that ok with pregnitude?

    • Amy

      I would think it would be fine but would ask your doctor if you are concerned.

  • Four leaf clover

    Hi Amy, I’m just trying to find pure myo-inositol online to take on its own as my pre-natal vitamin already supplies me with folic acid. I have looked up the metagenics websites and pure encspsulations website but still im only seeing inositol. I know that there are 9 versions of inositol and I only want myo-inositol. Can you recommend a website or specific brand? Thank you! P.s just found your site and love it! From ttc four leaf clover xx

    • Amy

      I think you would be safe with either. The inositol in the Metagenics Centinol is myo-inositol. The Pure formula is also myo-inositol.

  • Carly

    Hi Amy! Is Pregnitude ok to take if you have enodmetriosis, not PCOS?

    • Amy

      I’m not sure if it will help with endometriosis. I didn’t see that data but then again I wasn’t looking for it either.

  • Tanya-Marie

    where can I purchase it? I live in canada and cant seem to find it anywhere… I was diagnosed with PCOS 4 years ago even though my family doctor suspected it almost immediately after letting them know what was going on…. my partner dont want to do IVF until its a last resort and my RE is giving me the run around…. so we found Pregnitude online and cant seem to find it in canada.,… any responses as to where i could find it would be much appreciated!!!

    • Amy

      I believe Pregnitude is only available in the US market. It is sold as INOFOLIC in Europe.

      • Christina

        Can Canadians NOT buy it online and have it shipped to us?

        • Amy

          You may be able to purchase INOFOLIC which is the same product. Everett Labs only has rights to distribute their product in the US.

        • Wendy

          Try ordering from or (the later is cheaper. I don’t know if it will work, but you can try it.

  • Tanya-Marie

    so if I were to take the individual ingredience, would I take 2g Inositol and 200mcg Folic acid 2 times a day or would the dosage be lowered?

  • Dawn

    Hello – just curious is Pregnitude a brand name or Pregnenolone? Thanks.

    • Amy

      Dawn- Pregnitude is a brand name for myo-inositol plus Folic acid. In Europe it is INOFOLIC.

  • Azul


    My doctor prescribe me Loestrin 24 Fe to regulate my cycles, my question is:
    If its safe to take Pregnitude while I am in Loestrin? Because i wish to be in more
    control of the PCOS symptoms and the insulin resistance symptoms too.

    • Amy

      I would ask your doctor Azul.

  • Miran

    Hi Amy,

    I’m from Canada. My Gynecologist prescribed me with PregVit folic 5 and Metformin for fertility. Is Pregnitude and PregVit folic 5 are same? I guess Metformin will help to control my insulin? I don’t know what to believe anymore.

    Thanks so much for your blog. You really inspire me. I appreciate all your help. May God Bless you.


    • Amy

      Hi Miran-
      Thanks for the blessings! I looked up PregVit and it is a very different product. Pregnitude is just myo-inositol and folic acid.

  • krystal

    Can you tell me if pregnitude OK take with CoQ10 , dhea, or melatonin

    • Amy

      If you have questions about supplements ask your doctor, I would think it would be okay.

  • I’m interested in trying this product, have an appt in Feb with my doctor ( bout to move to IVF)

    I read using this product can help to prepare me for IVF by making the quality of my eggs better.

    I also see it might help bring down my cycle , but will it help me to grow eggs and ovulate ? I have a problem with both. If I can get prgnant on my own with out IVF then I will try that.

    • Amy

      Best of luck to you Jennifer. The research is very promising!

  • I had a miscarriage and I believe Metformin can help to prevent this.

    Does Pregnitude help with this as well ?

    • Amy

      Actually Jennifer, many miscarriages with PCOS are a result of low-progesterone early on in pregnancy. I have seen that myo-inositol helps with keeping gestational diabetes at bay.

  • taryn

    Hi there –
    I bought Pregnitude, but I’m not sure yet if I’m pregnant. My period isnt due for another week, would it be safe to start taking it if I’m not sure if I am pregnant?

    • Amy

      Taryn – I would talk to the folks at Pregnitude about this or ask your doctor.

  • JM

    Hi Amy,
    I am 39. My OB told me to try Pregnitude to help with becoming pregnant. I have only tried it for two days. I have had unpleasant gas and vomited. Not sure if this is caused by the supplement or not.
    Thank you for your time.

    • Amy

      I don’t this this is caused by Pregnitude. You can certainly call Everett Labs and ask them about side effects.

  • Is this medicine natural

    • Amy

      Yes, this is a form of b vitamin.

  • How long will it take for my periods to come on if I star pregnitude

  • Didi

    Is it possible to take pregnitude even if you’re not insulin resistant? I do have PCOS. I’m thin, live very healthy, but have polycystic ovaries. My cycles are irregular, I’m still not sure if I ovulate all the time and I have acne. I was able to regulate my cycles a little with vitex, but still haven’t got the result I was hoping for. Thanx

    • Amy

      I am not insulin resistant anymore and I found Pregnitude made me feel hypoglycemic. I think you would just have to try to see if it works for you.

  • Amber

    I just wanted to let everyone know that I have a group for women with pcos who are taking Pregnitude and we share our experiences with it, ttc or not. Thanks!

  • Pingback: Pregnitude….and I don’t mean pregnant with an attitude | Polishing the Sparkle()

  • Laura

    Has anyone had success with finding a similar product in Canada? I tried but they will not ship these items to Canada. I have also looked up INOFOLIC with no success.

    Thanks in advance!

    • Alittlemissconduct

      I found 100% myo-inositol powder on eBay from powdercity for a very reasonable price. Their website is and I would assume since you’re our neighbor to the north that shipping to Canada wouldn’t be a problem.

  • Katie

    I am already taking a multivitamin with 800mcg of folic acid. I am assuming that more is not needed, however, I would like to take the Pregnitude due to the high quality grade of the myo-inositol. Do you or anyone else reading this know if adding that much folic acid to the existing amount I’m taking is dangerous or toxic? Also, if it is, do you or anyone else reading this know what a good quality myo-inositol supplement would be and where to get it? Thank you in advance! Wonderful health to all!!

    • Amy

      I would just purchase myo-inositol powder from Pure Encapsulations or Metagenics – they do not contain folic acid.

  • Lyric

    what are the average results with pregnitude? my husband and i really want to get pregnant and have been trying for a year and it still has not happened. We are considering pregnitude.

    • Amy

      There have been lots of good anecdotal response from clients and followers. You might also look into OvaBoost.

  • Brenda

    Good day
    I am currently on clomid and Glucophage and trying to conceive for 4 years. I have just heard how Inofolic and Staminogro supplements can also help. Would you advise me to take these while taking the above fertility treatment?

    • Amy

      Read my articles about Pregnitude, Myo-inositol and Ovaboost. They are all very similar to Inofolic.

  • Heather Shannon

    Would it be safe to take with Royal Jelly, Maca Root, Wheatgrass tablets and Prenatal Vits?

  • MuzikGurl

    Can you take Ovaboost and Pregnitude at the same time? Also does this at all interfere with any ovulation pee stick test results? Cause I heard Clomid can just want to make sure. I also heard that Pregnitude can also help with weightloss as well (??)