What is Glucorein PCOS? - PCOS Diva
What is Glucorein PCOS?

Did you happen to catch the intriguing, FACES OF PCOS “Contest” that was advertised over all of PCOS social media this past summer?  FACES OF PCOS was sponsored by Napa Valley Nutritionals.  The company was looking for women to share their PCOS story.  I thought it was interesting that a relatively unknown supplement company was marketing a contest to women with PCOS.  They surely had something up their sleeve!

And so they did.  On September 18th, Napa Valley Nutritionals announced a new product to help with the management of PCOS.  I will admit, I am always skeptical of “new” products that pop up for women with PCOS.  I think companies are finally realizing that there is a huge business opportunity in PCOS.  Think about it, if at least 1 in 10 women have PCOS, and most of those women are struggling to control it, then there is a huge business opportunity for supplement companies.

With a healthy dose of skepticism, I reached out to Napa Valley Nutritionals to find out more about their new product, Glucorein Medical Food for Dietary Management of PCOS.  I discovered that Napa Valley Nutritionals is actually a  newly formed division of  Oculus a large commercial heathcare company. I had the opportunity to speak with Susan Derence, Sales and Marketing Director for Napa Valley Nutritionals last week. Susan actually has PCOS and has struggled with infertility and PCOS for many years.  She was very excited to talk about this new product.  She told me it has helped her bring on natural periods for the first time ever – she just turned 40.  She also has experienced lots of new hair growth.  The hair growth certainly peaked my interest since this is a symptom I still struggle with.

Susan explained that Glucorein’s main ingredient is chlorogenic acid. Each daily dose of Glucorein PCOS contains a therapeutic dose of 1 gram of chlorogenic acid.

If you watch Dr. Oz, you may have seen the episode in April about Weight Loss Supplements.  Green Coffee BeanExtract was one of the solutions discussed. Dr. Oz has made green coffee bean extract and chlorogenic acid all the rage. You can see the episode and more information here: http://www.doctoroz.com/videos/miracle-pill-burn-fat-pt-1 http://www.doctoroz.com/videos/green-coffee-bean-project?page=3#copy

PCOS Diva Advanced supplementsChlorogenic Acid

The active ingredient in the green coffee bean extract is chlorogenic acid, so Glucorein PCOS really isn’t anything new.  Chlorogenic acid has been on the market for a while – companies like Stevol provide it to supplement companies. You’ll find  it in products like this supplement from Vitamin World or this supplement from Puritan’s Pride.  But if you notice the amount in each product, you can see that you would need to take many pills to equal the therapeutic dosage of 1 gram in Glucorein PCOS.

Chlorogenic acid has specifically been shown to inhibit  enzyme, glucose-6-phosphatase, that promotes the formation of glucose (sugar) in the liver. So scientists believe it is the chlorogenic acid in coffee that may be responsible, at least in part, for the reduced risk of glycemic disorders like insulin resistance and diabetes. Other studies suggst that chlorogenic acid also slows the absorption of fat from food intake and it may also activate metabolism of extra fat.


The most recent study on green coffee bean was published in January 2012 in the Diabetes, Metabolic Syndrome and Obesity journal. The researchers followed a group of 16 adults who supplemented with chlorogenic acids at different dosages (either 700 or 1050 milligrams per day) for 12 weeks. All 16 adults were considered overweight, as demonstrated by a BMI of greater than 25 (a normal BMI is between 18.5 and 25). The subjects lost an average of almost 18 pounds – this was 10% of their overall body weight and 4.4% of their overall body fat.

If you drink a lot of coffee and are wondering if this would count instead for your chlorogenic acid dosage, roasted coffee isn’t a good source of chlorogenic acid. While roasting green coffee beans removes its naturally bitter taste of green coffee beans, it also removes a significant portion of chlorogenic acid. Green coffee beans remain one of the best natural sources for chlorogenic acid. Chloregenic acid has been shown in studies to control blood glucose, decrease insulin resistance, improve glucose tolerance and decrease plasma and liver lipids and lowers cholesterol all with little or no side effects.


Glucorein PCOS also contains .6grams of L-Cysteine.   L-Cysteine is a naturally occurring amino acid.  It is the natural origin compound of N-acetyl cysteine or NAC which is produced by chemical synthesis.  L-cysteine has shown to help reduce BMI, hirsutism, fasting insulin, free testosterone, menstrual irregularity and cholesterol levels. NAC has also been proven, in conjunction with Clomid, to increase ovulation and pregnancy rates in women previously deemed “Clomid-resistant”. It also has been shown to improve hair and nail tissue which may be the reason why Susan’s hair is growing back.

I have been using Glucorein PCOS for the past week.  I do feel different.  I feel more energized, my appetite is very stable and I really just feel good taking it.  I take an envelope and mix it with water.  It also has stevia, monk fruit (a Chinese fruit packed with antioxidants and Vitamin C) cranberry and lemon. It tastes like a slightly bitter and a little astringent and sour.  It almost tastes like a less sweet version powdered ice tea mix.

Glucorein products should be used under the supervision of a medical professional. It is $67.50 for a month supply.

BOTTOMLINE: I have asked Napa Valley Nutritionals to put me in touch with doctors that are using this supplement in their practice.  I did not received a response before my deadline to get this article published, so I don’t have any anecdotal clinical information to share. I wish there were more PCOS specific studies backing the health claims of Glucorein PCOS, but alas there are not.  I do think the chlorogenic acid studies as it relates to insulin resistance, as well as weight loss, are very promising. The research studies surrounding NAC and PCOS are also well known in the PCOS world.  I can tell you I like the way Glucorein PCOS makes me feel and I will continue to use if for 3 months and then reevaluate. As I receive more info about Glucorein PCOS, I will publish it on my site.

As with any supplement, it is important to talk to your doctor before taking.  Please share your experience with chlorogenic acid and NAC or L-cysteine in the comment section below or on my Facebook page.


More Resources:

  • Components Inhibit Amyloid Formation of Human Islet Amyloid Polypeptide in Vitro: Possible Link between Coffee Consumption and Diabetes Mellitus. J Agric Food Chem. 2011 Dec 28;59(24):13147-55. Epub 2011 Nov 21. Click Here for Article
  • Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial. Am J Clin Nutr. 2010 Apr;91(4):950-7. Epub 2010 Feb 24. Click Here for Article
  • Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance. Diabetes Care. 2009 Jun;32(6):1023-5. Epub 2009 Mar 26. Click Here for Article
  • Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on incretin hormones. Nutr Metab (Lond). 2011 Feb 7;8:10. Click Here for Article
  • Contribution of chlorogenic acids to the inhibition of human hepatic glucose-6-phosphatase activity in vitro by a standardized decaffeinated green coffee extract. J Agric Food Chem. 2010 Apr 14;58(7):4141-4.
  • Antidiabetic medicinal plants as a source of alpha glucosidase inhibitors. Curr Diabetes Rev. 2010 Jul;6(4):247-54. Review. Click Here for Article
  • “Coffee consumption and risk of type 2 diabetes in Finnish twins,” Int J Epidemiol, 33:3 (2004), 616-617. Click Here for Article
  • “Coffee consumption and risk of type 2 diabetes mellitus,” Lancet, 361:9358 (2003), 703-704. Click Here for Article
  • “Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine,” Am J Clin Nutr, 78:4 (2003), 728-733. Click Here for Article

12. “Coffee consumption and risk of type 2 diabetes mellitus,” Lancet, 360:9344 (2002), 1477-1478. Click Here for Article

10. “Coffee consumption and risk of type 2 diabetes mellitus,” Lancet, 361 (2003),702-704.

11. “Coffee consumption and risk for type 2 diabetes mellitus,” Ann Intern Med, 140:1 (2004), 1-8. Click Here for Article

12. N-acetylcysteine as an adjuvant to clompiphene citrate for successful induction of ovulation in infertile patients with Polycystic ovary syndrome. Salehpour S, Akbari Sene A, Saharkhiz N, Sohrabi MR, Moghimian F. J Obstet Gynaecol Res. 2012 Sep;38(9):1182-6. doi: 10.1111/j.1447-0756.2012.01844.x. Epub 2012 Apr 30.


  • Stephanie

    Where can I get this, and is it expensive? Im having a very hard time with PCOS and desperate to find something to help. Thanks

    • Stephanie

      Sorry, I just saw the full article now ( I couldnt view from phone). thank you!!

  • MariannaF

    Are you taking this along with Pregnitude?

    • Amy

      I actually had to stop taking Pregnitude because I was finding it was regulating my blood sugar too low and I was feeling very hypo-glyemic. But everyone is different. I don’t feel the same way with Glucorein but is works differently.

  • Cathy Wolfe

    Can this be taken with Pregnitude?

    • Amy

      I would imagine that you can but I would talk to your doctor.

  • Mandy

    I tried using the promo code PCOSDIVA but it does not work. Did the code already expire? I would love to try it but if I can buy two and get one free that would be even better.

    • Amy

      I don’t believe so. I would contact Napa Valley Nutritionals.

  • Laura

    Thanks for the great post! Curious if that good, energized feeling lasted past the first week and if you’ve decided to keep taking it regularly? I feel like I’ve tried so many things, but would like to give this a shot.

    • Amy

      Yes Laura, I am still taking it and still feeling good!

  • Tiffany

    Does Glucorein help with regulating cycles also? Im only 22 and was advise to just have a hystorectomy to “fix” my PCOS. I feel to young and still would like to have children of my own. Just wanting to make sure this would be worth the money before i purchased it. Also any other hints/tips are appriciated

    • Amy

      Yes Tiffany it does help with regulating cycles. Please get a second opinion about a hysterectomy. That will not cure PCOS as it is an endocrine disorder not an ovary issue. YOu should also consider purchasing my meal plans or at least follow the free Dinner ideas I have on my site. Diet and lifestyle play a huge roll in managing PCOS.

  • Sophia

    Would you take this along with metformin or in place of? I want to call my endocrinologist and ask if he knows about it.

    • Amy

      I believe you can take this along with metformin. I would call Napa Valley Nutritionals as well. They should be able to answer your question.

  • Heather

    Hi, is there any new updates from taking the Glucorein? Have you noticed anything with hair regrowth or fall out?? I’m very interested in trying this out.

    • Amy

      I can’t say that the Glucorein has helped hair growth. My hair is falling out right now due to telogen effluvium. I do see a lot of regrowth but I dont think I can say for certain it is a result of glucorein.

  • C3ri

    Hi Amy 🙂 Are you still using this product? What are your thoughts on it now? I’m curious about this, but there are so few testimonials out there. There seems to be another site, who has been asked to use it like you, and is offering the same deal – so I feel a little skeptical. I would really like to know if you continued use or if you found it didn’t make a big enough difference to justify continued use. Also, would love to hear from any other ladies who’ve bought the product.

    • Amy

      Yes I am still using Glucorein. I do notice the days that I don’t take it. I feel less clarity and a little less energy. I can’t speak to hair growth because I had a big shed in the fall and the doctor believes it is a result of telogen effluvium. My cycles have been very regular too. I am going to take it another 3 months and then write a follow-up article. In full disclosure Glucorein has paid for the advertisement on my site and their Ad states the promotion they are offering. The product is a bit pricy but compared to competitors chlorogenic acid – it is comparable for the amount of cholorgenic acid (1g) you get in a daily dose.

  • Holly

    Just wondering why you need to be under doctor supervision if you can get this supplement OTC? What if my doctor has not heard of it and is unwilling to let me try it?

    • Amy

      Yes you can get this OTC. I would bring the study info to your doctor.

      • Holly

        I did and I am on my 4th day and I could definitely tell the difference on day one!! I don’t feel that sluggish feeling after I eat a meal and I don’t get hungry until lunch time! So far I am pleased with how I feel….I did find that I had to let the powder sit and “dissolve” quite a bit before it stirred in all the way or else I was drinking huge chunks in the water lol. Excited to see what consistent use will bring me…maybe a baby 🙂

  • Cathy

    Now that you have taken it for a while, any help with weight loss?

    • Amy

      I am really at my set weight and don’t need to lose weight. It helps my energy level and clarity.

  • Gemma

    Hi Amy – this sounds promising – but I have a pretty intense caffeine allergy. Do you know how many milligrams of caffeine (if any) this product contains?

    • Amy

      THis product does not contain caffeine.

  • I also was wondering why it has to be under a doctor’s supervision. Did they tell you why they state this? Is it because of blood sugar reactions (hypoglycemia)?

  • dally s.

    hello everyone.. just wanted to say that yesterday i spoke to my doctor he been helping women with fertility issues for almost 30 yrs. He told me that Glucorein works like Metformin but it doesnt have any side effects because its all natural ingredients. He also said that Glucorein will help the pancrea and the ovaries to funtion properly and it will help regulate periods..he said that alot of women are taking it and its really giving great results. I been dealing with my PCOS for like 11 years im 29 yrs old and let me tell u that its not easy living with this crap.. The doctor wants me to take Glucorein for 3 months and then he will start my treatment so i can get pregnant soon.. I will keep u guys posted my next doctor’s visit will be in 6 wks. Yah guys are welcome to leave me any questions or comments…

  • Jill


    It has been 3 months. Do you have an update for us? I’m very curious! 🙂


    • Amy

      I am planning on one soon- I still love the way it makes me feel.

  • dorina

    So whats better the green coffee extract or the glucorein

    • Amy

      They are essentially the same thing but Glucorein has an added PCOS supplement.

  • Lina

    Have you posted an update that I have missed? I really would like to know your “results” and opinion on this product. Thanks 🙂

    • Amy

      I have not yet Lina but plan to soon. I am still taking it and like the energy and clarity that it gives me.

      • Jennifer

        Hi Amy! I was wondering if you had a chance to post an update on the Glucorein?? I am currently taking Pregnitude (going on my 5th month now) and I haven’t seen much of a difference and have only had 2 real cycles during this time. I am thinking about switching to something else and I am curious about the Glucorein. Does it contain the mylol insoltol?? Thank you!

        • Amy

          It is coming in the June Newsletter. It doesn’t contain myo-inositol.

  • Mari

    Hey Amy,

    Did you happen to post an update. Almost a year now and I finally read this article. Not sure how I missed it. I’m not planning to have kids right now, I’m just trying to be super healthy and give myself a fighting chance. This product sounds almost perfect for me because I struggle with my sugar levels, hypo-glycemic. I would love to hear an update. It’s nearly impossible for me to find a doctor in my state that knows anything about PCOS


  • Sarah

    Now that it’s two years later, are you still taking it? Have you had any new hair growth or positive results?

    • Amy

      I do still take Glucorein. I love the energy and mental clarity it provides.

  • staphyjb

    I have been taking Ovasitol with NAC on the side now for 2 months and so far no period. I have been reading about the new Glucorein supplement and am curious about adding that to my regimen. I noticed Glucorein already has Myo-Inositol and NAC in it (although the Myo-Inositol is at a much lower dose). As such, would it be better just to stick with Ovasitol because it has a much higher dose of Myo-Inositiol along with the recommended D-Chiro-Inositol – which I hear is important to complement the Myo-Inositol. Should I just take a high quality green coffee bean supplement in addition to Ovasitol, which in essence would mimic Glucorein but would include D-Chiro-Inositol and would include a higher amount of Myo-Inositol. Do you know of a good green coffee supplement? Does anybody have any suggestions with that?