Ultra Thyroid Care - PCOS Diva
Spring Renewal: FREE 5-Day Mini Course Starting April 8th
X

Ultra Thyroid Care

A unique blend of nutrients and botanical extracts to support healthy thyroid function and promote proper hormone levels.*

$42.99 60 servings

Ultra Thyroid Care

$42.99

16 in stock

SKU: PCDTHS-PL Categories: ,
Save with a Subscription!

Our Ultra Thyroid Care provides a unique blend specifically designed to offer top quality nutrients and precious botanical extracts to support healthy thyroid function and promote proper hormone levels.*

HIGHLIGHTS:*

American Ginseng root — Helps support a normal response to stress, normal blood glucose
metabolism, along with a balanced conversion of thyroid hormone.*
Coleus forskohlii extract — Promotes the proper function of TSH, a hormone which stimulates
the synthesis and secretion of T3 and T4 thyroid hormones.* This herb also supports the normal
breakdown of body fat to use as energy.*
Selenium — This mineral is a key constituent in the conversion of T4 to the more active T3.
Additionally, selenium supports the generation of a very powerful antioxidant known as glutathione,
and reduces the effects of free radicals and mercury to the thyroid gland.*
Potassium Iodide — A source of iodine. Iodine is an essential component of thyroid hormones
and is necessary for normal thyroid function. If the body is deficient in iodine, the thyroid will have
trouble making enough thyroid hormone. Potassium is included as it is necessary for getting thyroid
hormones into our cells, and is a critical electrolyte needed for healthy cellular function.*
Tyrosine and Copper — Support the natural production of “feel good” compounds such as dopamine
and norepinephrine, which promote a healthy mood.* Tyrosine is also the amino acid building block
from which thyroid hormone is synthesized.
Chromium, Zinc and Manganese — These minerals are needed for support of the thyroid gland by
supporting the metabolic pathways that maintain insulin, glucose and cholesterol regulation.*

SCIENCE BEHIND

Coleus forskohlii
Coleus forskohlii belongs to the same botanical family that includes mint, oregano, basil and sage. It grows primarily in the subtropical
temperate climates of India, Nepal, Sri Lanka and Thailand, and the root portion has a long tradition of use in Hindu and Ayurvedic
medicine.10 Its active constituent, forskolin, is believed to be responsible for virtually all the biological activities attributed to Coleus
forskohlii. It is a lipid-soluble molecule that penetrates cell membranes and activates the enzyme adenylate cyclase, which increases
intracellular levels of cyclic AMP (cAMP).11 cAMP is an important messenger compound for the biological response to hormones and other
extracellular signals. It is required for proper cellular communication in the hypothalamus and pituitary gland, and for regulating feedback
control of hormones. With regard to thyroid hormones, TSH binds to receptors on the basal membrane of thyroid epithelial cells, followed by elevation of cAMP and a subsequent cascade of phosphorylation reactions, the final step of which is secretion of T4 and a small amount of T3.12 Cyclic AMP promotes thyroid hormone secretion and stimulates lipolysis in adipose tissue.13 Adipocytes from obese
women have lower adenylate cyclase activity than those of non-obese women.14 Promoting adenylate cyclase activity and
stimulating cAMP production may be helpful for fat loss, and weight gain or inability to lose weight are among the classic
signs of hypothyroidism. Animal and in vitro studies support a potential role for Coleus forskohlii in enhancing lipolysis
and reducing body weight and fat accumulation.15-17 The effects of forskolin on fat loss in humans have been modest but
considering how difficult it is for those with thyroid dysfunction to lose body fat, modest effects should not be disregarded.
In a small but promising study of overweight women, twice daily supplementation Coleus forskholii extract for eight weeks
resulted in decreases in body fat percentage even in the absence of changes in diet or exercise habits.18 A separate study
in mildly overweight women concluded that forskolin may not be powerful for fat loss but it could be helpful for preventing
fat gain, and it may help reduce hunger and fatigue.19

American Ginseng, Copper
The non-stimulating adaptogenic botanical American Ginseng (Panax quinquefolius) helps control variations in cortisol
and may also ameliorate stress-induced decreases in dopamine and serotonin.22 It also supports healthy blood glucose
levels and insulin sensitivity,23 which may have a favorable impact on body weight. Copper is a required cofactor for
the enzyme dopamine β-hydroxylase, which catalyzes the conversion of dopamine to norepinephrine, which influences
lipolysis and fat burning.

Tyrosine, Potassium Iodide, and Selenium
Tyrosine, iodine, and selenium are essential for the production of thyroid hormones and conversion of T4 to T3. As much as
80% of the body’s iodine is concentrated in the thyroid gland.3 In addition to its role as a raw material for thyroid hormone, tyrosine is also a building block for dopamine, which can help support a positive mental outlook, motivation and goal-setting. (Individuals with hypothyroidism often experience depression and/or apathy.) Apart from its role in facilitating conversion of T4 to T3, selenium is needed
for a form of glutathione peroxidase highly expressed in the thyroid gland, where it catalyzes the degradation of
peroxides generated during thyroid hormone synthesis.4

Vitamin A
The importance of vitamin A for thyroid function is typically eclipsed by iodine and selenium but this nutrient is a crucial
factor for healthy thyroid function. It is required for the activation of thyroid hormone receptors; insufficient vitamin
A may depress thyroid function. Research tells us that TTR (transthyretin), an extracellular transfer protein in humans,
is responsible for binding both T4 and T3 with a preference for T4. This protein also binds vitamin A, known to be
important for thyroid function. TTR is an extracellular transport protein involved in the distribution of thyroid hormones
and vitamin A. Hypothyroid patients may have a yellow-orange coloring to their skin due to poor conversion of beta-carotene to vitamin A—a conversion that also requires zinc.
Animal models have shown that vitamin A deficiency interferes with thyroid health starting further upstream, in the
pituitary gland.5 Vitamin A insufficiency increases pituitary synthesis and secretion of TSH, increases the size of the
thyroid gland, and reduces uptake of iodine by the thyroid gland. Vitamin A given alone, even in the absence of increased
iodine, has demonstrated a positive impact on thyroid function and gland size in humans.6 Vitamin A supplementation
was shown to reduce serum TSH levels and increase T3 in premenopausal women, including a cohort of obese women,
who are at increased risk for subclinical hypothyroidism.7 Among children with goiter living in areas where iodine
deficiency disorders are prevalent, the greater the severity of vitamin A deficiency, the greater the thyroid gland volume
and the higher the TSH levels.8 Compared to placebo, supplemental vitamin A significantly reduced median TSH and the
rate of goiter. In rats with concurrent deficiencies in both iodine and vitamin A, vitamin A repletion alone, even without
iodine, was effective in reducing thyroid gland size and hyperstimulation.9

Chromium, Zinc and Manganese
These minerals promote healthy thyroid hormone levels by supporting insulin sensitivity and maintenance of healthy
blood glucose levels. Elevated insulin opposes the action of epinephrine and can impede thyroid hormone production, so
optimizing gluco-regulation may facilitate thyroid hormone synthesis and cellular receptivity. Chromium has long been
recognized as a key player in insulin sensitivity and glycemic control.20 Zinc plays a role in insulin-mediated glucose uptake,
so it may contribute to maintaining insulin sensitivity and healthy blood glucose levels. Additionally, zinc is responsible for
the “zinc finger” structure that stabilizes the nuclear receptor that responds to thyroid hormone.21

 

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

 

References
1. Rowsemitt C, Najarian T. TSH is Not the Answer: Rationale for a New Paradigm to Evaluate and Treat
Hypothyroidism, Particularly Associated with Weight Loss. Thyroid Science 6(4):H1-16, 2011.
2. Najarian T, Rowsemitt C. Hypothyroidism, Particularly Associated with Weight Loss: Evaluation and
Treatment based on Symptoms and Thyroid Hormone Levels. Thyroid Science 6(6):CR1-7, 2011.
3. Oregon State University. Linus Pauling Institute Micronutrient Information Center. Iodine. Updated Aug
2015. https://lpi.oregonstate.edu/mic/minerals/iodine.
4. Oregon State University. Linus Pauling Institute Micronutrient Information Center. Selenium. Updated Nov
2014. https://lpi.oregonstate.edu/mic/minerals/selenium.
5. Oregon State University. Linus Pauling Institute Micronutrient Information Center. Vitamin A. Updated Jan
2015. https://lpi.oregonstate.edu/mic/vitamins/vitamin-A.
6. Hess SY. The impact of common micronutrient deficiencies on iodine and thyroid metabolism: the
evidence from human studies. Best Pract Res Clin Endocrinol Metab. 2010;24(1):117-132. doi:10.1016/j.
beem.2009.08.012.
7. Farhangi MA, Keshavarz SA, Eshraghian M, Ostadrahimi A, Saboor-Yaraghi AA. The effect of vitamin A
supplementation on thyroid function in premenopausal women. J Am Coll Nutr. 2012;31(4):268-274. doi:1
0.1080/07315724.2012.10720431.
8. Zimmermann MB, Wegmüller R, Zeder C, Chaouki N, Torresani T. The effects of vitamin A deficiency
and vitamin A supplementation on thyroid function in goitrous children. J Clin Endocrinol Metab.
2004;89(11):5441-5447. doi:10.1210/jc.2004-0862.
9. Biebinger R, Arnold M, Langhans W, Hurrell RF, Zimmermann MB. Vitamin A repletion in rats with
concurrent vitamin A and iodine deficiency affects pituitary TSHbeta gene expression and reduces
thyroid hyperstimulation and thyroid size. J Nutr. 2007;137(3):573-577. doi:10.1093/jn/137.3.573.
10. Alasbahi RH, Melzig MF. Plectranthus barbatus: a review of phytochemistry, ethnobotanical uses and
pharmacology – Part 1. Planta Med. 2010;76(7):653-661. doi:10.1055/s-0029-1240898.
11. Alasbahi RH, Melzig MF. Forskolin and derivatives as tools for studying the role of cAMP. Pharmazie.
2012;67(1):5-13.
12. Textbook of Biochemistry by Thomas Devlin. Fifth Edition, p. 880, 883.
13. Alternative Medicine Review. Coleus Forskohlii Monograph. No authors listed. Vol 11, No 1. p. 47-51.
14. Martin LF, Klim CM, Vannucci SJ, Dixon LB, Landis JR, LaNoue KF. Alterations in adipocyte adenylate
cyclase activity in morbidly obese and formerly morbidly obese humans. Surgery. 1990;108(2):228-235.
15. Litosch I, Hudson TH, Mills I, Li SY, Fain JN. Forskolin as an activator of cyclic AMP accumulation and
lipolysis in rat adipocytes. Mol Pharmacol. 1982;22(1):109-115.
16. Schimmel RJ. Stimulation of cAMP accumulation and lipolysis in hamster adipocytes with forskolin. Am J
Physiol. 1984;246(1 Pt 1):C63-C68. doi:10.1152/ajpcell.1984.246.1.C63.
17. Han LK, Morimoto C, Yu RH, Okuda H. Effects of Coleus Forskohlii on Fat Storage in Ovariectomized
Rats. Yakugaku Zasshi. 2005;125(5):449-453. doi:10.1248/yakushi.125.449.
18. Badmaev V, Majeed M, Conte A, Parker J. (2002). Diterpene Forskolin (Coleus forskohlii, Benth.):
A possible new compound for reduction of body weight by increasing lean body mass. NutraCos –
Nutraceuticals. 1. 6-7.
19. Henderson S, Magu B, Rasmussen C, et al. Effects of coleus forskohlii supplementation on body
composition and hematological profiles in mildly overweight women. J Int Soc Sports Nutr. 2005;2(2):54-
62. doi:10.1186/1550-2783-2-2-54.
20. A scientific review: the role of chromium in insulin resistance. No authors listed. Diabetes Educ.
2004;Suppl:2-14.
21. Oregon State University. Linus Pauling Institute Micronutrient Information Center. Zinc. Updated Feb
2019. https://lpi.oregonstate.edu/mic/minerals/zinc.
22. Rasheed N, Tyagi E, Ahmad A, et al. Involvement of monoamines and proinflammatory cytokines in
mediating the anti-stress effects of Panax quinquefolium. J Ethnopharmacol. 2008;117(2):257-262.
doi:10.1016/j.jep.2008.01.035.
23. Szczuka D, Nowak A, Zakłos-Szyda M, et al. American Ginseng (Panax quinquefolium L.) as a Source of
Bioactive Phytochemicals with Pro-Health Properties. Nutrients. 2019;11(5):1041. Published 2019 May 9.
doi:10.3390/nu11051041.

Reviews

There are no reviews yet.

Be the first to review “Ultra Thyroid Care”

Your email address will not be published. Required fields are marked *